Fractional CO2 laser treatment for deep pitted scars works by sending laser energy through the skin to ablate the scarred superficial skin, and stimulate the skin's own collagen production. Most patients require only one treatment with the Fractional CO2 laser. Some improvement is seen quickly, even before your two week follow up appointment. Jun 13, · Topical retinoids such as tazarotene have been proven to be an effective treatment in the battle to minimize the appearance of deep acne scars. As a derivative of vitamin A, the antioxidant properties in topical retinoids heal .