The Philadelphia chromosome The most common abnormality in the leukemia cells of people with ALL is the Philadelphia (Ph) chromosome. The Ph chromosome is a translocation, or . Abstract Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic Cited by:
About % of adult patients with acute lymphoblastic leukemia show the Philadelphia (Ph) chromosome. Few series have evaluated the prognosis of additional cytogenetic alterations (ACA) to the Ph chromosome. We analyzed the frequency, type and prognostic significance ofACA in adults Cited by: 6. What Is Philadelphia Chromosome Positive ALL?